Mayo, Florida is a town and the only municipality in Lafayette County, Florida, United States. It is the county seat of Lafayette County. The population was 1,055 at the 2020 census. Although the current Town of Mayo was settled and established in 1874 by John B. Whitfield, the town was not officially incorporated as a municipality until 1903. Whitfield d…Mayo, Florida is a town and the only municipality in Lafayette County, Florida, United States. It is the county seat of Lafayette County. The population was 1,055 at the 2020 census. Although the current Town of Mayo was settled and established in 1874 by John B. Whitfield, the town was not officially incorporated as a municipality until 1903. Whitfield decided to name the town after James M. Mayo, who was a colonel in the Confederate States Army.
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