The Kansas City Chiefs will take on the Los Angeles Chargers in Week 1 of the 2025 NFL season. Find out how to watch, listen, and stream.

After 17 training camp practices and three preseason games, it is officially a game week for the Kansas City Chiefs. On Friday, they are set to take on the L.A. Chargers in Sao Paulo, Brazil.

Despite his reputation as a big game player, last season ended in disappointment as Kansas City fell to the Philadelphia Eagles in the Super Bowl, a loss that still stings. Now, Mahomes is tasked with leading the Chiefs back to the mountaintop, beginning with a season-opening matchup against the Los Angeles Chargers in São Paulo.

The game will be broadcast by YouTube. In Kansas City, it also will be shown on KSHB (Channel 41). The game will also be broadcast on radio via KFNZ (96.5 FM) in the KC area, and KNSS (98.7 FM) in the Wichita area. The Chiefs opened as a 3 1/2-point favorite, with the over/under set at 46 1/2.

For the first time, an NFL game has been exclusively streamed for free (no subscription required) on the YouTube platform.

During Sunday's press conference, Kansas City Chiefs DB Trent McDuffie commented on potential Los Angeles Chargers threat Ladd McConkey | @EdEastonJr

Najee Harris said he is expects to play against the Chiefs on Friday in Brazil: “I’m ramping up to it.” Did not want to get into any details on what happened in the fireworks accident. Said his vision has not been affected and called the eye injury “superficial.” pic.twitter.com/T7xoqDVodX