The three-judge panel in San Francisco also upheld the fraud conviction of Holmes’ former business partner and lover Ramesh “Sunny” Balwani — as well as a lower’s court order for the two to pay $452 million in restitution.

Elizabeth Holmes, the disgraced founder of Theranos, will remain in prison after losing a bid Monday to overturn her fraud conviction, with a federal appeals court saying she hadn’t proved there were legal missteps during her trial for defrauding investors with false claims of what her blood-testing startup could achieve.