Binding of a ligand to the native three-dimensional configuration of a protein increases protein stability, with a corresponding increase in the protein’s melting temperature. This indirect ...

A new study published ahead-of-print by SLAS Discovery describes an evaluation of microplate-based high-throughput cellular thermal shift assay (CETSA HT) performed at AstraZeneca to assess its ...

CETSA Is Now Being Used Routinely to Demonstrate Small Molecule’s Engagement of a Specific Target in the Cell The cellular thermal shift assay (CETSA) was first described approximately 2 years ago by ...

The search for new drugs, including those for cancer, is set to speed up thanks to a new research technique invented by scientists at the Nanyang Technological University (NTU). Named the "Cellular ...

The cellular thermal shift assay (CETSA) is a powerful tool for confirming target engagement and deconvoluting mode of action in living cells. The principle behind CETSA is that a ligand – target ...

Named the “Cellular Thermal Shift Assay” (CETSA), scientists can now know for sure if a drug had reached its target protein in the body, which is a critical step in determining the effectiveness of ...

Researchers have developed the first method for directly measuring the extent to which drugs reach their targets in the cell. The method could make a significant contribution to the development of new ...

Historically, knowledge of drug targets has largely lagged far behind the administration of drugs to patients, often with harmful or even deadly results. Various advances suggest that the ...

The search for new drugs, including those for cancer, is set to speed up thanks to a new research technique which could tell if drugs had reached their intended target. The search for new drugs, ...