The San Francisco 49ers return to Levi's Stadium to face the Los Angeles Chargers in their final preseason game of 2025. This matchup marks the 51st preseason meeting all-time between the two teams and the first since 2023. San Francisco looks to improve its record to 28-23 in...

Brock Purdy, Christian McCaffrey, Trent Williams, Nick Bosa, Fred Warner, George Kittle and Deommodore Lenoir should all be sitting out. A handful of potential starters may suit up to help solidify their status atop the depth chart, but that core group should strictly be focused on the regular season opener Sept. 7.