The anti-tumor immune response involves a series of complex steps mediated by various immune cells and signaling molecules.

TG4050 elicits strong polyepitopic, polyclonal, durable cytotoxic and effector neoantigen-specific CD8 T cell responses Results reinforce TG4050 ...

Encephalitis is an inflammation of the brain that can be caused by infections or autoimmune reactions. Even when patients survive the acute phase, many are left with long-lasting neurological problems ...

Higher levels of CD4-positive naïve T cells in patients receiving CAR T-cell therapy for multiple myeloma are associated with ...

Researchers have not only identified how two immune cells work together to fight cancer but also revealed the cascade of molecules that help coordinate this attack. The ecosystem that surrounds a ...

CD8 + cytotoxic T lymphocytes (CTLs) serve as central effectors in cancer immunotherapy by directly eliminating tumor cells. However, current clinical therapies face significant limitations. These ...

In a recent study published in Nature Immunology, researchers investigated the direct influence of sodium (Na+) ions on the cytotoxic cluster of differentiation 8 (CD8)-expressing T cells and hence on ...

Cytotoxic T cells are star players in the adaptive immune system, enforcing protection against invading viruses or cancer cells. However, evidence has been mounting that the cells may also deal a ...

Cancer cells employ a variety of strategies to evade the immune system, and modern immunotherapies aim precisely at these ...

Balancing the immune system is a delicate act. If it’s too weak, infections and cancer can take hold; if it’s too strong, autoimmune diseases or transplant rejection can occur. Researchers have ...