Cocaine addiction may persist because the drug rewires brain circuits through a protein called DeltaFosB. This buildup ...

Addiction is one of the most intensely studied conditions in modern medicine, yet even with high‑resolution brain scans and genetic tools, scientists still cannot fully explain why some people get ...

Why someone becomes addicted to a substance has long baffled scientists and philosophers. Now leading researchers are getting the clearest picture yet of how addiction works in the brain and body.

“I don’t understand why he just can’t stop abusing alcohol.” Turns out that addiction is a whole lot more complicated than just saying “no.” Although the stigma of addiction as a moral failing ...

Researchers have used mouse models to study how cocaine addiction alters the brain, illuminating why relapse is common as ...

Remarkable scientific progress over the past five decades has helped us develop knowledge of how drugs of abuse induce pleasure, reinforce use, and lead to the compulsive self-administration we call ...

A mouse study highlights the role of acetylcholine in behavioral flexibility, offering new insight into the brain mechanisms involved in addiction and obsessive compulsive disorder.

For weeks, Steele, an assistant professor of psychiatry at the Yale School of Medicine, and members of his lab have traveled to an addiction treatment center in Middletown, Connecticut, where they are ...