Over the past decade, small molecule kinase inhibitors have emerged as promising therapeutics, particularly in oncology. Through data that has emerged during this period, it has become increasingly ...

Kinases are enzymes that catalyze the transfer of phosphate groups from high-energy donor molecules to specific target molecules. These intracellular phosphorylation cascades initiated by protein ...

The Transcreener ADP 2 Assay uses a highly selective antibody and far-red fluorescent tracer to directly detect ADP produced by any ADP-producing enzyme (i.e. kinases, ATPases, helicases, carboxylases ...

In 1987 I attended a meeting at Cold Spring Harbor on phosphatidylinositol signaling that turned out to be pivotal for me. A few years earlier I'd helped show that a phosphatidylinositol (PI) kinase ...

Association of insulin-like growth factor-1 receptor (IGF1R) expression in circulating tumor cells (CTCs) with E-cadherin (E-CAD) expression and improved survival in breast cancer (BC). This is an ...

The discovery could serve as a starting point for antiviral strategies. A research team at Ruhr University Bochum, Germany, ...