Three families of polytopic proteases with membrane-embedded active sites have been discovered: site 2 proteases (S2Ps) are metalloproteases, presenilin-type aspartyl proteases are represented widely ...

Endoplasmic reticulum–associated degradation (ERAD) is a cellular protein quality-control process that disposes of proteasomal substrates from the early secretory pathway. Recent work shows that the ...

Rhomboid pain is felt under the neck between the shoulder blades and spine. It’s sometimes referred to as shoulder blade pain or upper back pain. The rhomboid muscle is located in the upper back. It ...

If you’re hoping to improve your posture and strengthen your back, you’ll want to work out your rhomboid muscles. The way you stand or sit shows how well your joints and muscles are working. Poor ...

Please could you tell us a little bit about rhomboid enzymes? Where are they found and what do they do? Rhomboid enzymes live in the cell’s membrane where their job is to cut the anchors of proteins, ...

Rhomboid proteases are a promising target for new drugs. Now researchers from the Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) have uncovered a mechanism for regulating enzyme ...

Rhomboid proteases are evolutionary conserved intramembrane serine proteases. Because of their emerging role in many important biological pathways, rhomboids are potential drug targets. Unfortunately, ...