Nat Clin Pract Neurol. 2008;4(3):159-169. Drug Primary clinical use Protective effect during administration in animal models? Effects of withdrawal in EAE Clinical study Phenytoin Treatment of ...

Atomic-level studies of the architecture of tiny sodium channel proteins, critical to generating electrical signals that start off each beat of the heart, are imparting striking details about their ...

The transport of ions to and from a cell is controlled by pore-forming proteins embedded in the cell membrane. In particular, voltage-gated sodium channels (VGSCs) govern the transfer of sodium (Na +) ...

A study on live tissue cells is the first to reveal how channels that allow sodium to enter into breast cancer cells enable tumors to grow and spread. The discovery adds to evidence which suggests ...

Ion channels are structures within cell membranes that enable specific ions to travel to and from the cell. Such transfer is essential for a variety of physiological processes such as muscle cell ...

Inwardly rectifying potassium (Kir) channels are gated by the membrane phospholipid phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P 2). Among them, Kir3 requires additional molecules, such as the ...

Neuropathic pain syndromes remain a major therapeutic challenge, despite considerable research efforts during the past few decades. Many hypotheses about the mechanisms of pain generation have been ...

Hypernatremia refers to sodium levels in the blood being too high. Common causes include inadequate fluid intake, or fluid loss. Sodium plays an essential role in functions such as muscle contraction, ...

A new study on live tissue cells is the first to reveal how channels that allow sodium to enter into breast cancer cells enable tumours to grow and spread. The discovery adds to evidence which ...