Misbehaving T cells light up long before Parkinson’s symptoms show, zeroing in on vulnerable brain proteins. Their early ...

Mutations in the PINK1 gene are a frequent cause of autosomal recessive Parkinson’s disease (PD). PINK1 encodes a mitochondrial kinase with neuroprotective activity, implicated in maintaining ...

LJI scientists have discovered that T cells may help detect Parkinson's disease years before motor symptoms appear. Your T ...

First discovered more than 20 years ago, PINK1 is a protein directly linked to Parkinson’s disease, but until now, no one has seen what human PINK1 looks like, or how PINK1 attaches to the ...

PINK1 is the second most commonly mutated gene in autosomal recessive Parkinson's disease (PD). The PINK1 gene encodes a 581 amino acid serine–threonine kinase, which is cleaved at its N ...

First, PINK1 senses mitochondrial damage. Then, it attaches to damaged mitochondria. Once attached, it links to a protein ...

Your T cells work hard to fight disease. Unfortunately, "friendly fire" from T cells can sometimes harm the body's healthy ...

Scientists have finally pinned down a protein that’s largely responsible for Parkinson’s disease. Known as PINK1, the protein has been linked to the disease for decades but its structure and ...

PINK1 docks onto the surface of damaged mitochondria, becomes activated, and marks them with ubiquitin, this tagging initiates the clean-up process, ensuring that damaged mitochondria do not harm ...

Top: PINK1 bound to its ubiquitin substrate (red) and stabilized by an antibody fragment (grey). Bottom: Key PINK1 features (right) include a stabilizing C-terminus region (CTR), a catalytic ...