Researchers advance understanding of single guide RNA (sgRNA) design to optimize CRISPR/Cas9 cutting efficiency using an explainable AI model. Researchers at Oak Ridge National Laboratory (TN, USA) ...
The gene editing tools based on CRISPR/Cas9 include CRISPR knockout (CRISPR KO), CRISPR interference (CRISPRi), and CRISPR activation (CRISPRa). The action mechanism of CRISPR/Cas9 in cells in three ...
In a recent study published in Gene Therapy, researchers utilize the CRISPR-Cas9 system to induce the synthesis of dopamine (DA) in the brains of a rat model for Parkinson’s disease (PD). Study: ...
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