Gut

LY6D identifies persistent stem-like cells driving pancreatic tumourigenesis

Background Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy characterised by remarkable cellular ...
Gut

Zinc-dependent RNA-binding protein controls hepatocyte senescence and recovery from alcohol-related liver failure

Background Why alcohol-associated liver disease (ALD) resolves after abstinence in most people but progresses to liver ...
Gut

Role of A2 beta casein in milk-induced eosinophilic oesophagitis: novel in-vivo and in-vitro findings

We read with interest the article by Santacroce about personalised medicine in eosinophilic oesophagitis (EoE) and the ...
gut.bmj

Rectal non-steroidal anti-inflammatory drugs and post-ERCP pancreatitis: it is time for the next chapter in prophylaxis

After innumerable negative or inconclusive studies to find a pharmacological prophylactic for post-ERCP pancreatitis (PEP), two randomised trials in the USA1 and China2 ushered a new era of ...
gut.bmj

CNNM4: a ferroptotic vulnerability in cholangiocarcinoma

Cholangiocarcinoma (CCA) represents one of the most aggressive malignancies affecting the biliary tree, with limited treatment options and high mortality rates. Despite recent advances in molecular ...
gut.bmj

PEG is back: revisiting the role of pegylated interferon alfa and benchmarking its place in HBV cure strategies

Functional cure, defined as sustained HBsAg loss with off-treatment viral suppression, is the ultimate goal of antiviral therapy for chronic hepatitis B.1 Yet with current standard-of-care ...
gut.bmj

The Asia-Pacific Colorectal Screening score: a validated tool that stratifies risk for colorectal advanced neoplasia in asymptomatic Asian subjects

1 Department of Medicine, National University of Singapore, Singapore, Singapore 2 Department of Internal Medicine, National Taiwan University, Taipei, Taiwan 3 Department of Medicine and Therapeutics ...
gut.bmj

Diffusion-weighted magnetic resonance without bowel preparation for detecting colonic inflammation in inflammatory bowel disease

1 Inserm, U954 and Department of Hepato-Gastroenterology, University Hospital of Nancy, Vandoeuvre-lès-Nancy, France 2 Departement of Radiology, University Hospital of Nancy, Vandoeuvre-lès-Nancy, ...
gut.bmj

Increased uptake and improved outcomes of bowel cancer screening with a faecal immunochemical test: results from a pilot study within the national screening programme in England

3 NHS Bowel Cancer Screening Midlands and North West Programme Hub, Rugby, UK 4 NHS Bowel Cancer Screening Southern Programme Hub, Guildford, UK 5 University of Surrey, Guildford, UK Correspondence to ...
gut.bmj

Melatonin improves abdominal pain in irritable bowel syndrome patients who have sleep disturbances: a randomised, double blind, placebo controlled study

Background and aims: Melatonin, a sleep promoting agent, is involved in the regulation of gastrointestinal motility and sensation. We aimed to determine if melatonin was effective in improving bowel ...
gut.bmj

Combination of carvedilol with variceal band ligation in prevention of first variceal bleed in Child-Turcotte-Pugh B and C cirrhosis with high-risk oesophageal varices: the ...

Correspondence to Professor Shiv Kumar Sarin, Hepatology, Institute of Liver and Biliary Sciences, New Delhi, Delhi 110070, India; shivsarin{at}gmail.com Objectives Beta-blockers and endoscopic ...
gut.bmj

Gut origin of sepsis: a prospective study investigating associations between bacterial translocation, gastric microflora, and septic morbidity

AIMS To investigate the “gut origin of sepsis” hypothesis. METHODS Prospective controlled study of 279 surgical patients in which cultures of nasogastric aspirates were compared with those obtained ...