In the early days of President Donald Trump's second term, Alaska Sen. Lisa Murkowski had openly challenged or rebuked him at least three times.

Sen. Lisa Murkowski said Thursday she will vote against Secretary of Defense nominee Pete Hegseth, who is facing a barrage of accusations about his personal conduct, making the Alaska Republican the first in her party to oppose one of President Donald Trump’s cabinet picks.

Pete Hegseth has vowed to bring his “warrior” ethos to the Pentagon. Democrats had assailed him as unfit for the job, and his confirmation came down to Vice President JD Vance serving as tiebreaker.

Pete Hegseth is on track to be secretary of defense, despite Murkowski's opposition. He has denied multiple allegations of alcohol abuse, financial mismanagement and violence against women.

Alaska U.S. Sen. Lisa Murkowski on Thursday announced on social media that she would vote against confirming Pete Hegseth to lead the U.S. Department of Defense.

Three Republicans voted with every Democrat against Trump’s controversial pick to lead the Pentagon, forcing Vance to step in and put Hegseth over the top.

Sen. Lisa Murkowski's husband, Verne Martell, has always been supportive of her political career. Here's what to know about their marriage.

A Princeton and Harvard-educated former combat veteran, Hegseth went on to make a career at Fox News, where he hosted a weekend show. Trump tapped him as the defense secretary to lead an organization with nearly 2.1 million service members, about 780,000 civilians and a budget of $850 billion.

The Senate narrowly advanced the nomination of Pete Hegseth as President Donald Trump’s defense secretary on Thursday in a 51-49 vote, moving him one step closer to confirmation despite fierce objections from Senate Democrats and mounting unease among some Republicans.

The Senate’s 50-50 vote for Pete Hegseth marked the second time in history that a vice president was called upon to break the tie to confirm a Cabinet official.

At a contentious confirmation hearing, Sen. Dan Sullivan struck a familiar note by posing “the most important question” to Pete Hegseth. Because a confirmation hearing isn't all about the nominee.

Murkowski is a moderate with a history of bucking her party and Trump when she has felt it was the right thing to do.