How major nuclear protein complexes control specialized gene regulation in cancer and beyond

Precision and timing of gene expression is essential for normal biological functions and, when disrupted, can lead to many ...

CRISPR discovery could lead to single diagnostic test for COVID, flu, RSV

Across all domains of life, immune defenses foil invading viruses by making it impossible for the viruses to replicate. Most ...
IEEE

Attention Integrated Residue CNN for Classification of DNA-Binding and RNA-Binding Proteins

Abstract: The classification of DNA-binding proteins (DBPs) and RNA-binding proteins (RBPs) is essential for understanding molecular interactions and regulatory functions. However, the existing ...
Phys.org

New study shows how DNA is recognized by proteins that control gene expression

With a new study in the journal Cell, researchers at Stanford University and Stockholm University have contributed to increased knowledge about gene regulation in human cells. How genes are turned on ...
Science Daily

Ancient DNA reveals the deadly diseases behind Napoleon’s defeat

Researchers have uncovered microbial evidence in the remains of Napoleon’s soldiers from the 1812 Russian retreat. Genetic analysis revealed pathogens behind paratyphoid and relapsing fever, diseases ...
Fast Company

How I took control of my email address with a custom domain

Over the past three years, I’ve changed email providers three times without ever changing email addresses. That’s because my address is entirely under my control. Instead of relying on an email that ...
The New Yorker

The Family Fallout of DNA Surprises

Lily Wood is forty-three years old but considers April 9, 2019, to be her “rebirth day.” That was the date she received her results from Ancestry, the direct-to-consumer DNA-testing company. A ...
PNAS

De novo design of protein binders to stabilize monomeric TDP-43 and inhibit its pathological aggregation

Pathological aggregation of TDP-43, predominantly driven by its low-complexity domain, is a central driver of many neurodegenerative diseases, including amyotrophic lateral sclerosis and ...
Scientific Research Publishing

Mandell, J.G. and Barbas, C.F. (2006) Zinc Finger Tools: Custom DNA-Binding Domains for Transcription Factors and Nucleases. Nucleic Acids Research, 34, W516-W523.

ABSTRACT: Prostate cancer is reported to be the second most common cancer in men. At this time, there exist over 20 FDA-approved drugs for the treatment of prostate cancer. These include alkylating ...
C&EN

RNA Binding Mechanism of the FUS Zinc Finger in Concert with Its Flanking Intrinsically Disordered Region

Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. The zinc finger (ZnF) motif is one of the most common nucleic acid binding motifs in ...
eLife

Interpretable protein-DNA interactions captured by structure-sequence optimization

This valuable work presents an interpretable protein-DNA Energy Associative (IDEA) model for predicting binding sites and affinities of DNA-binding proteins. While the method is convincing, it ...