A method for arrayed CRISPRi screening in organoids enables the investigation of morphogenesis in human stem cell-derived tissues, revealing the roles of ZIC2, SOX11, and ZNF521 in neural tube closure ...
Chinese scientists have successfully developed an embryonic disc-like gastrulation model known as Disc-Gastruloid, unlocking a long-standing "black box" of early human embryonic development and organ ...
Liu, Huang, Shen, Shao, Jing and collaborators combine single-cell transcriptomics with Patch-seq and metabolomics to dissect primate anterior insular cortex. They identify two von Economo neuron (VEN ...
1. The 300,000-Person Waiting List and the '14-Day Void' One of the cruelest imbalances in modern medicine is the overwhelming shortage of organs for transplantation. According to statistics, while ...
Version of Record: This is the final version of the article. This is a wonderful and landmark study in the field of human embryo modeling that uses patterned human gastruloids and conducts a ...
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