DNA replication dynamics in cells from higher eukaryotes follows very complex but highly efficient mechanisms. However, the principles behind initiation of potential replication origins and emergence ...
The MCM helicase is broadly bound across the genome, and its phosphorylation is antagonistically regulated by the kinase DDK and the phosphatase RIF1–PP1. TRESLIN–MTBP recognises the phosphorylated ...
Scientists have uncovered how DnaA, the master key to DNA replication, opens the door to bacterial growth. This breakthroughpaves the way for new antibiotics to combat the rising tide of antibiotic ...
Using single-molecule DNA nanomanipulation, we show that abortive initiation involves DNA "scrunching"--in which RNA polymerase (RNAP) remains stationary and unwinds and pulls downstream DNA into ...
This is a preview. Log in through your library . Abstract Sparse 3T3 cells, in excess serum, become quiescent in the early G 1 (or G 0) phase of the cell cycle if the cells are cultured in low ...
Every living cell transcribes DNA into RNA. This process begins when an enzyme called RNA polymerase (RNAP) clamps onto DNA. Within a few hundred milliseconds, the DNA double helix unwinds to form a ...
Solution to duplicating the eukaryotic genome 3 billion bps in the human genome. About 50,000 replication origins/genome. Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news ...
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