San Francisco 49ers star wideout Deebo Samuel left his team's home game against the Kansas City Chiefs on Sunday with an illness and was later ruled out.

The San Francisco 49ers just lost yet again to the Kansas City Chiefs, this time by a score of 28-18. Here are the 49ers' grades for this embarra ...

San Francisco 49ers wide receiver Brandon Aiyuk left Sunday's game with a knee injury and has been ruled out for the remainder of the contest. Aiyuk ...

Brock Purdy’s three interceptions for the 49ers with no touchdown passes led to a career-low 36.7 passer rating.

San Francisco 49ers star Deebo Samuel has long been considered one of the best players, and best athletes, in the NFL, but ...

Kyle Shanahan evaluated the team's Week 7 loss to the Kansas City Chiefs and shared postgame injury updates on WR Brandon Aiyuk and others.

The San Francisco 49ers fear that wide receiver Brandon Aiyuk tore his right ACL on Sunday, according to coach Kyle Shanahan, ...

The San Francisco 49ers' Super Bowl hangover isn't going away easily, with the Kansas City Chiefs sending them below .500 on ...

The 49ers were without three of their top playmakers for much of the matchup, with running back Christian McCaffrey (Achilles ...

Brandon Aiyuk was carted off from the sideline before halftime Sunday. Aiyuk was injured with 37 seconds left in the half ...

Already missing one of their top three receivers, the 49ers ruled out Brandon Aiyuk (knee) and Deebo Samuel (illness) for the ...

San Francisco 49ers rookie receiver Ricky Pearsall made his NFL debut exactly 50 days after being shot in the chest during a ...