Understanding human gene function in living organisms has long been hampered by fundamental differences between species.

Genetic disorders occur due to alterations in the primary genetic material—deoxyribonucleic acid (DNA)—of an organism.

CRISPR–Cas9-based therapies are widely investigated for their clinical applications. However, there are limitations ...

Picture CRISPR-Cas9, a gene editing technology, as a GPS-guided scalpel: gRNA directs the Cas9 enzyme, a protein that cuts ...

Researchers at The University of Tokyo developed TECHNO, a two-step genome editing strategy that replaces entire mouse loci ...

Discover the innovative TECHNO platform for full-length gene humanisation, enhancing models for human gene function.

Scientists first read the human genome, a three-billion-letter biological book, in April 2003. Since then, researchers have steadily advanced the ability to write DNA, moving far beyond single-gene ...

As genetic engineering technologies such as clustered regularly interspaced short palindromic repeats (CRISPR) improve and ...

Understanding human gene function in living organisms has long been hampered by fundamental differences between species. Although mice share most ...

Genetic disorders occur due to alterations in the primary genetic material, deoxyribonucleic acid (DNA), of an organism.