PINK1 is a mitochondrial kinase and is responsible for activation and transportation of Parkin from the cytoplasm to impaired mitochondria (Bingol and Sheng, 2016). Parkin is a cytosolic E3-ubiquitin ...

Misbehaving T cells light up long before Parkinson’s symptoms show, zeroing in on vulnerable brain proteins. Their early ...

LJI scientists have discovered that T cells may help detect Parkinson's disease years before motor symptoms appear. Your T ...

A neurological tsunami is looming over India as projections reveal a staggering 168% surge in Parkinson's disease (PD) cases ...

Your T cells work hard to fight disease. Unfortunately, "friendly fire" from T cells can sometimes harm the body's healthy ...

"You can see that T cell reactivity before diagnosis," says Sette. In fact, T cell reactivity to PINK1 was at an all-time high before diagnosis. Sette warns against jumping to conclusions. Parkinson's ...

Your T cells work hard to fight disease. Unfortunately, "friendly fire" from T cells can sometimes harm the body's healthy ...

Figure 4. pink1 knockout mitigates protein aggregation upon proteasomal inhibition. (A) Western blot analysis of ubiquitin levels in the insoluble protein fraction of HEK293 cells following the ...

In HEK293 cells, pink1 -/- cells served as a negative control for PINK1 (Figure 2B and 2C) and for pUb (Figure 2D and 2E). While the Western blot using the pUb antibody displayed some nonspecific ...