Misbehaving T cells light up long before Parkinson’s symptoms show, zeroing in on vulnerable brain proteins. Their early ...

LJI scientists have discovered that T cells may help detect Parkinson's disease years before motor symptoms appear. Your T ...

First discovered more than 20 years ago, PINK1 is a protein directly linked to Parkinson’s disease, but until now, no one has seen what human PINK1 looks like, or how PINK1 attaches to the ...

Your T cells work hard to fight disease. Unfortunately, "friendly fire" from T cells can sometimes harm the body's healthy ...

“PINK1 senses this damage and docks to the surface of mitochondria. Once positioned on the mitochondrial surface, PINK1 becomes active and seeks out a small protein known as ubiquitin and marks it.

PINK1 is the second most commonly mutated gene in autosomal recessive Parkinson's disease (PD). The PINK1 gene encodes a 581 amino acid serine–threonine kinase, which is cleaved at its N ...

Scientists have finally pinned down a protein that’s largely responsible for Parkinson’s disease. Known as PINK1, the protein has been linked to the disease for decades but its structure and ...

First, PINK1 senses mitochondrial damage. Then, it attaches to damaged mitochondria. Once attached, it links to a protein ...

PINK1 docks onto the surface of damaged mitochondria, becomes activated, and marks them with ubiquitin, this tagging initiates the clean-up process, ensuring that damaged mitochondria do not harm ...

First discovered in 2001, the protein PINK1 has been directly linked to Parkinson’s disease.However, until now, scientists had been unable to visualize human PINK1 or understand how it is switched on ...

In Parkinson’s disease, mutations in PINK1 and Parkin can result in the accumulation of damaged mitochondria in the brain, leading to the tremors and stiffness that are the hallmarks of the ...