Improvements in medical therapy, carotid-artery stenting, and carotid endarterectomy call into question the preferred ...

This feature about a man hospitalized for uncomplicated diverticulitis who is found to have high blood pressure offers a case vignette accompanied by two essays, one supporting watchful waiting and ...

The management of carotid-artery stenosis that has not caused recent symptoms — asymptomatic carotid stenosis — has been controversial. Clinical trials that began more than 30 years ago showed a small ...

Sometimes, as patients near the end of life, eliciting and fulfilling a simple wish can lead to acceptance and a peaceful death — a lesson absorbed by a physician during a week of ice cream.

To the Editor: The landmark findings of the CheckMate 816 trial, conducted by Forde et al. (Aug. 21/28 issue), 1 showed a significant survival benefit with neoadjuvant nivolumab plus chemotherapy in ...

Explore this issue of The New England Journal of Medicine (Vol. 393 No. 19).

More than 470,000 patients with kidney failure receive hemodialysis in the United States alone, with worldwide estimates approaching 3 million patients. Mortality from kidney failure remains ...

Explore this issue of The New England Journal of Medicine (Vol. 393 No. 18).

In the management of breast cancer, treatment approaches are locoregional (i.e., surgery and radiotherapy) or systemic (i.e., chemotherapy, targeted therapy, endocrine therapy, and immunotherapy). The ...

Personalized therapies hold tremendous promise but challenge traditional models of drug and biologic development. The FDA outlines a path to market entry for products where a randomized trial is no ...

We conducted an international, open-label, randomized, blinded-outcome-assessment trial involving 1284 patients who had undergone successful catheter ablation for atrial fibrillation at least 1 year ...