Abstract: Drug-Target Affinity (DTA) prediction plays a crucial role in drug discovery, and accurate DTA prediction can significantly reduce the cost of drug development. While most studies focus on ...

Obesity is one of the greatest burdens of global public health. One major factor that drives obesity is excessive fat accumulation. Despite decades of research, the biological processes that trigger ...

Introduction Critically ill patients commonly develop acquired neutrophil dysfunction, which increases susceptibility to intensive care unit-acquired infection (ICU-AI). This study aimed to assess ...

Just one weekly puff from an asthma-like inhaler might one day protect you from the viral infections that make winters miserable – and could even save your life in the event of another pandemic. That ...

Kevin K. Yang, Sarah Alamdari, Alex J. Lee, Kaeli Kaymak-Loveless, Samir Char, Garyk Brixi, Carles Domingo-Enrich, Chentong Wang, Suyue Lyu, Nicolo Fusi, Philip Rosenfield, Neil Tenenholtz, Ava P.

Inside each cell of the human body are proteins that control which genes are expressed at the right place and time. However, intriguingly, many of the most important proteins involved in gene ...

This valuable work presents an interpretable protein-DNA Energy Associative (IDEA) model for predicting binding sites and affinities of DNA-binding proteins. While the method is convincing, it ...

Abstract: Protein-protein interactions (PPIs) play a crucial role in cellular biochemical reactions. Computationally mining PPI can help us better understand cellular regulatory mechanisms. Most ...

Maria Rottersman of UC Davis holds a loaf of baked bread made using seed varieties developed without alpha-gliadin proteins, a component of gluten. (Alejandra Andrade / California Wheat Commission) ...

The coevolution of mammals and viruses has been an arms race of sorts. Part of our defense against viruses comes from the innate immune response, which includes specific cell types and intracellular ...