San Francisco 49ers wide receiver Brandon Aiyuk left Sunday's game with a knee injury and has been ruled out for the remainder of the contest. Aiyuk ...

Brock Purdy’s three interceptions for the 49ers with no touchdown passes led to a career-low 36.7 passer rating.

San Francisco 49ers star Deebo Samuel has long been considered one of the best players, and best athletes, in the NFL, but ...

Kyle Shanahan evaluated the team's Week 7 loss to the Kansas City Chiefs and shared postgame injury updates on WR Brandon Aiyuk and others.

The San Francisco 49ers' Super Bowl hangover isn't going away easily, with the Kansas City Chiefs sending them below .500 on ...

Already missing one of their top three receivers, the 49ers ruled out Brandon Aiyuk (knee) and Deebo Samuel (illness) for the ...

The 49ers were without three of their top playmakers for much of the matchup, with running back Christian McCaffrey (Achilles ...

Brandon Aiyuk was carted off from the sideline before halftime Sunday. Aiyuk was injured with 37 seconds left in the half ...

Already missing one of their top three receivers, the 49ers ruled out Brandon Aiyuk (knee) and Deebo Samuel (illness) for the ...

San Francisco 49ers rookie receiver Ricky Pearsall made his NFL debut exactly 50 days after being shot in the chest during a ...

San Francisco 49ers star wideout Deebo Samuel left his team's home game against the Kansas City Chiefs on Sunday with an illness and was later ruled out.

Kareem Hunt rushed for two first half touchdowns Sunday as the Kansas City Chiefs became the only unbeaten team in the NFL ...