This rare insertion has been identified in three Japanese families with disorders in the frontotemporal dementia (FTD) spectrum, although some members have been diagnosed with Parkinson’s disease (PD) ...

What goes wrong first in the Alzheimer’s disease brain? Scientists led by Marc Aurel Busche of the U.K. Dementia Research Institute at University College London may have an answer. In the May 7 Neuron ...

Cytotoxic T cells are star players in the adaptive immune system, enforcing protection against invading viruses or cancer cells. However, evidence has been mounting that the cells may also deal a ...

Talk about a closely watched study. Conference after conference, Roche scientists running the ongoing Brain Shuttle AD trial of trontinemab are dispensing morsels of news from sequential interim ...

Signaling through the TREM2 receptor fuels an ever-growing list of known microglial functions in the brain, and gene variants that hobble TREM2 signaling beckon Alzheimer’s disease. Ergo, activating ...

As the baby boom generation reaches its hopefully golden years, scientists have been projecting a doubling of dementia cases in the U.S. by 2050, alarming health care agencies, the public, and health ...

Identifying genes that control protein levels could provide insight into disease development and progression. However, genetic analyses such as genome-wide associated studies identify regions ...

APOE4 strongly increases the risk of sporadic Alzheimer’s disease. Yet some carriers evade the disease entirely. Now, scientists led by Richard Mayeux, Caghan Kizil, and Badri Vardarajan of Columbia ...

In Phase 3, HMTM failed to meet co-primary endpoints. Subgroup analysis of an open-label extension suggests benefit in people with MCI. In that subgroup, half as many people transitioned to AD. HMTM ...

Research over the last decade has shown that aggregated Aβ seeds can be transferred between people during rare medical procedures, sparking amyloidosis in the recipient. Could this result in ...

Part 2 of 2. Click here for Part 1. What happens in the brain of a person with fatal ARIA? Researchers now have one of their first detailed looks at the pathology of this rare and calamitous condition ...