Klubnik, who sprained his ankle in the Tigers’ win over Boston College last week, could see his streak of 34 consecutive starts for Clemson come to an end Saturday against SMU. Clemson’s starting left tackle Tristan Leigh was also listed as questionable.

The injury comes at the worst possible time for a struggling Clemson team.

ESPN's matchup predictor, which offers a prediction model based on its college football power index (FPI) ratings and other variables, gives Clemson a 63.3% chance to win and SMU a 36.7% chance.

The Patriots are a 7-point favorite over the Titans in NFL Week 7 odds, courtesy of BetMGM.

Clemson has posted two wins against the spread this season.