Physiologic role of glycocalyx The glycocalyx plays a key role in microvascular and endothelial physiology, in particular by regulating micro-vascular tone and endothelial permeability, …

Abstract Preclinical studies in animals and human clinical trials question whether the endothelial glycocalyx layer is a clinically important permeability barrier. Glycocalyx breakdown products …

Mar 30, 2012 · The potential relevance of endothelial activation biomarkers to sepsis has been raised in both this journal and others [1 – 3]. Biomarkers for sepsis associated with the …

Mar 22, 2007 · Glycocalyx (GLX) is implicated in mechanotransduction of shear stress and microvascular blood flow. We tested whether GLX loss accounts for the microvascular …

Jun 2, 2008 · Introduction Postischemic injury to the coronary vascular endothelium, in particular to the endothelial glycocalyx, may provoke fluid extravasation. Shedding of the glycocalyx is …

The glycocalyx is a layer that coats the luminal sur-face of vascular endothelial cells [10]. Following cardiac surgery, pro-inflammatory factors are triggered, leading to glycocalyx …

Sep 14, 2013 · Introduction Recent data suggested an interaction between plasma constituents and the endothelial glycocalyx to be relevant for vascular barrier function. This might be …

Measure-ments of glycocalyx or inflammatory biomarkers would be helpful to support our pathophysiological hypoth-esis on the protective efect of albumin on the vascular wall. Finally, …

Nov 28, 2023 · The luminal surface of the vascular endothelium is lined by the endothelial glycocalyx (eGC), a gel‐like carbohydrate‐rich structure. In sepsis, heparanase‐1 (HPA‐1) …

Clinically, glycocalyx and endothelial cell damage are associated with pathophysiologic sequels like capillary leakage and tissue edema, accelerated inflam-mation and platelet activation, …