1TG8: The structure of Dengue virus E glycoprotein - RCSB PDB
May 28, 2004 · Dengue virus, a member of the Flaviviridae family, has a surface composed of 180 copies each of the envelope (E) glycoprotein and the membrane (M) protein. The crystal structure of an N-terminal fragment of E has been determined and compared with a …
Structural Proteomics of Dengue Virus - PMC - National Center for ...
The structural proteins include capsid (C), membrane protein (prM/M) and envelope (E). prM and E are released from the polyprotein by signalase cleavage in the ER, but remain anchored on the luminal side of the membrane.
The key amino acids of E protein involved in early flavivirus infection ...
Jul 3, 2021 · According to the structure and functions, flavivirus envelope protein (E protein) monomers are divided into three domains (domain I, domain II and domain III) and two regions (stem region and transmembrane region).
Structure of the dengue virus envelope protein ... - Nature
Jan 22, 2004 · Dengue virus enters a host cell when the viral envelope glycoprotein, E, binds to a receptor and responds by conformational rearrangement to the reduced pH of an endosome. The conformational...
Structure of Dengue Virus: Implications for Flavivirus …
Mar 3, 2002 · The E protein dimers in mature virus (A) are shown undergoing a rearrangement to the predicted T = 3 fusogenic structure (C) with a possible intermediate (B). Arrows in (B) indicate the direction of E rotation. The solid triangle in (C) indicates the position of a quasi-3-fold axis.
Structure of the dengue virus envelope protein after membrane …
Jan 22, 2004 · Dengue virus enters a host cell when the viral envelope glycoprotein, E, binds to a receptor and responds by conformational rearrangement to the reduced pH of an endosome. The conformational change induces fusion of viral and host-cell membranes.
New insights into the immunopathology and control of dengue …
Nov 25, 2015 · Dengue virus is a relatively simple positive-sense single-stranded RNA virus that is 50 nm in diameter and has three structural proteins — capsid (C) protein, precursor membrane (prM) protein...
Dengue overview: An updated systemic review - ScienceDirect
Oct 1, 2023 · The core is surrounded by two well-known proteins, membrane (M) and envelope Proteins (E), which create the lipid envelope [13]. In addition, non-structure proteins play essential roles in regulation of DENV replication such as immunological regulation, inducing vascular leakage, assisting vRNA synthesis and dengue polyprotein cleavage.
Functional analysis of dengue virus (DENV) type 2 envelope protein ...
The DENV envelope (E) protein is composed of three domains: E protein domain I (ED1) is the central domain, ED2 is the dimerization domain and contains the conserved fusion loop, and ED3 is the putative receptor-binding domain (Modis et al., 2003).
Receptors and routes of dengue virus entry into the host cells
Feb 25, 2015 · DENV structure consists of a 50-nm-diameter particle with a lipid envelope to which two structural proteins are associated, the membrane (M) and the envelope (E) proteins (Mukhopadhyay et al., 2005; Perera and Kuhn 2008).